Novel endogenous engineering platform for robust loading and delivery of functional mRNA by extracellular vesicles
A. M. Zickler, X. Liang, D. Gupta, D. Mamand, M. de Luca, G. Corso, L. Errichelli, J. Hean, T. Sen, O. M. Elsharkasy, N. Kamei, Z. Niu, G. Zhou, H. Zhou, S. Roudi, , S. EL Andaloussi
This paper develops an mRNA delivery system using extracellular vesicles engineered with RNA-binding domains and fusogenic moieties, showing improved efficacy in a melanoma model.
bioRxiv · Mar 17, 2023Bioengineering