S. EL Andaloussi

This paper describes a protocol to generate human posterior axial assembloids from pluripotent stem cells, demonstrating multi-lineage differentiation and tissue complexity.

This study shows that extracellular vesicles promote myogenic differentiation in C2C12 cells, but their effectiveness depends on dose, collection media, and isolation method.

This paper develops VEDIC and VFIC systems for efficient intracellular protein delivery using engineered extracellular vesicles, achieving high recombination and genome editing efficiency in vitro and in vivo.

This paper develops an mRNA delivery system using extracellular vesicles engineered with RNA-binding domains and fusogenic moieties, showing improved efficacy in a melanoma model.

The paper introduces a high-throughput method called single particle profiler (SPP) to analyze content and biophysical properties of nanoscale bioparticles, demonstrating its application on mRNA encapsulation, viral binding, and biophysical heterogeneity.

This study uses combined atomic force and fluorescence microscopy to analyze molecular and biophysical features of single extracellular vesicles from different cell lines, revealing correlations and heterogeneity in their properties.