G. Corso

PLINDER: The protein-ligand interactions dataset and evaluation resource

PLINDER provides a large, annotated PLI dataset with diverse annotations and improved evaluation splits to better assess computational methods for drug design.

Snorkel-tag Based Affinity Chromatography for Recombinant Extracellular Vesicle Purification

This paper introduces a Snorkel-tag system for affinity purification of extracellular vesicles using CD81 fused with tags and transmembrane domains, enabling non-destructive isolation and future applications in tracing and analyzing EVs.

Novel endogenous engineering platform for robust loading and delivery of functional mRNA by extracellular vesicles

This paper develops an mRNA delivery system using extracellular vesicles engineered with RNA-binding domains and fusogenic moieties, showing improved efficacy in a melanoma model.

A dual sequence and culture-based survey of maize rhizosphere protists reveals dominant,plant-enriched, and culturable community members

This study compares culture-based and sequencing methods to analyze maize rhizosphere protists, showing distinct communities and challenges in isolating dominant taxa.

Engineering of extracellular vesicles for display of protein biotherapeutics

This paper develops a platform to display multiple protein therapeutics on extracellular vesicles, showing improved efficacy in inflammatory disease models compared to existing biologics.

Impaired cholesterol metabolism in the mice model of cystic fibrosis. A vicious circle?

This study examines cholesterol metabolism in CF mice, finding a vicious cycle where altered bile salts lead to reduced cholesterol absorption, increased biosynthesis, and liver inflammation.