Targeting a Therapy-Resistant Cancer Cell State Using Masked Electrophiles as GPX4 Inhibitors
J. K. Eaton, L. Furst, R. A. Ruberto, D. Moosmayer, R. C. Hillig, A. Hilpmann, K. Zimmermann, M. J. Ryan, M. Niehues, V. Badock, A. Kramm, S. Chen, P. A. Clemons, S. Gradl, C. Montagnon, , S. L. Schreiber
This paper identifies nitrile oxide electrophiles as a new class of GPX4 inhibitors that overcome limitations of existing chloroacetamide-based inhibitors.
bioRxiv · Sep 5, 2018Biochemistry