Author

L. Furst

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Organism:non-human primate· 1

Frequent Co-Authors

J. K. Eaton· 3 shared V. S. Viswanathan· 3 shared G. Xing· 2 shared K. Dave· 2 shared M. J. Wawer· 2 shared P. Chatterji· 2 shared A. Hilpmann· 1 shared A. Kramm· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersCancer Biology

J. K. Eaton

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Author profile →

4 papers

Recent·Most cited

Validation of ferroptosis in canine cancer cells to enable comparative oncology and translational medicine

P. Chatterji, G. Xing, L. Furst, K. Dave, Q. Zhou, D. V. LaBarbera, D. A. Thamm, J. K. Eaton, M. J. Wawer, V. S. Viswanathan

This study validates ferroptosis in canine cancer cells, showing similar responses to human cells, supporting dogs as a model for developing ferroptosis-based cancer therapies.

bioRxiv · Apr 28, 2024 · PreprintCancer Biology

The enzyme glutamate-cysteine ligase (GCL) is a target for ferroptosis induction in cancer

J. K. Eaton, P. Chatterji, L. Furst, S. Basak, A. M. Patel, Y. Y. Sweat, L. L. Cai, K. Dave, R. A. Victoria, E. Pizzi, J. Noorbakhsh, G. Tian, J. A. S. Roth, J. Hynes, G. Xing, , V. S. Viswanathan

This study identifies GCL inhibition as a strategy to induce ferroptosis in cancer cells, introducing novel inhibitors with potent cellular activity.

bioRxiv · Apr 28, 2024 · PreprintCancer Biology

Tissue remodeling and cell signaling underpin changes in tumor microenvironment heterogeneity in glioma oncogenesis

M. Dinevska, S. S. Widodo, L. Furst, L. Cuzcano, Y. Fang, S. Mangiola, P. J. Neeson, P. K. Darcy, R. G. Ramsay, F. MacKay, S. S. Stylli, T. Mantamadiotis

The paper shows that glioma progression involves changes in immune cell infiltration, extracellular matrix deposition, and signaling heterogeneity, with implications for therapy.

bioRxiv · Dec 5, 2021Cancer Biology

Targeting a Therapy-Resistant Cancer Cell State Using Masked Electrophiles as GPX4 Inhibitors

J. K. Eaton, L. Furst, R. A. Ruberto, D. Moosmayer, R. C. Hillig, A. Hilpmann, K. Zimmermann, M. J. Ryan, M. Niehues, V. Badock, A. Kramm, S. Chen, P. A. Clemons, S. Gradl, C. Montagnon, , S. L. Schreiber

This paper identifies nitrile oxide electrophiles as a new class of GPX4 inhibitors that overcome limitations of existing chloroacetamide-based inhibitors.

bioRxiv · Sep 5, 2018Biochemistry