BiochemistrybioRxiv
Targeting a Therapy-Resistant Cancer Cell State Using Masked Electrophiles as GPX4 Inhibitors
J. K. Eaton, L. Furst, R. A. Ruberto…·S. L. Schreiber
This paper identifies nitrile oxide electrophiles as a new class of GPX4 inhibitors that overcome limitations of existing chloroacetamide-based inhibitors.
DOI 10.1038/s41589-020-0501-5