S. L. Schreiber

Bicyclic pyrrolidine inhibitors of Toxoplasma gondii phenylalanine t-RNA synthetase with antiparasitic potency in vitro and brain exposure

This paper describes new bicyclic pyrrolidine inhibitors of Toxoplasma gondii PheRS with improved potency, selectivity, and brain exposure compared to previous azetidine-based inhibitors.

Highly specific intracellular ubiquitination of a small molecule

The paper identifies a small molecule, BRD1732, that is ubiquitinated in cells, leading to proteasome inhibition through accumulation of ubiquitin chains.

Bifunctional small molecules that induce nuclearlocalization and targeted transcriptional regulation

This paper develops bifunctional molecules that induce nuclear localization and transcriptional regulation, showing their potential for therapeutic applications in cancer.

Rational screening for cooperativity in small-molecule inducers of protein-protein associations

The paper introduces a binding-based screen to identify cooperative small-molecule inducers of protein-protein interactions, identifying a compound with high cooperativity comparable to classical molecular glues.

Diversity-oriented synthesis encoded by deoxyoligonucleotides

The paper describes the design, synthesis, and validation of a 3.7 million-member DNA-encoded library using diversity-oriented synthesis to enhance structural diversity for drug discovery.

DNA-encoded library (DEL)-enabled discovery of proximity-inducing small molecules

This paper uses DNA-encoded libraries to discover small molecules that induce protein-protein associations between BRD4 and VHL-elongin C-elongin B.

Mapping the landscape of genetic dependencies in chordoma

This study identifies essential genes in chordoma using CRISPR screens, revealing new therapeutic targets like PTPN11 and confirming known dependencies such as TBXT.

Reference compounds for characterizing cellular injury in high-content cellular morphology assays

The paper profiles 218 cytotoxic and nuisance compounds in U-2 OS cells to create reference compounds for improving assay optimization and compound prioritization in cellular morphology assays.

Modulation of ferroptosis sensitivity by TXNRD1 in pancreatic cancer cells

This study shows that reducing TXNRD1 in pancreatic cancer cells increases resistance to ferroptosis by boosting GPX4 levels, highlighting context-specific ferroptosis regulation.

Multimodal small-molecule screening for human prion protein binders

This study screens for small-molecule binders of the human prion protein using multiple methods but finds only a weak binder with no therapeutic potential.

PALP: An imaging method for detecting and quantifying polyunsaturated phospholipids via peroxidation

The paper introduces PALP, an imaging method that detects and quantifies polyunsaturated phospholipids by inducing peroxidation with laser pulses, enabling non-invasive monitoring of lipid unsaturation and ferroptosis in live cells.

Characterization of the prion protein binding properties of antisense oligonucleotides

This study examines the binding and antiprion properties of antisense oligonucleotides (ASOs) targeting prion protein (PrP), finding that sequence-independent binding and aggregation occur, but only PrP-lowering ASOs are effective in vivo.

Renal medullary carcinomas depend upon SMARCB1 loss and are sensitive to proteasome inhibition

This study identifies SMARCB1 loss as critical for RMC survival and shows proteasome inhibition as a potential therapeutic strategy.

Targeting a Therapy-Resistant Cancer Cell State Using Masked Electrophiles as GPX4 Inhibitors

This paper identifies nitrile oxide electrophiles as a new class of GPX4 inhibitors that overcome limitations of existing chloroacetamide-based inhibitors.

High throughput screen identifies IFN-γ-dependent inhibitors of Toxoplasma gondii growth

This study identifies IFN-γ-dependent inhibitors of Toxoplasma gondii growth through a high-throughput screen and characterizes their mechanisms of action.