D. Murphy

Same data, different results? Machine learning approaches in bioacoustics

The paper evaluates machine learning methods for caller identity classification in mammalian vocalizations, finding Mel-frequency cepstral coefficients and random forests provide consistent results across datasets.

Distinct Type 1 Immune Networks Underlie the Severity of Restrictive Lung Disease after COVID-19

The paper identifies distinct type 1 immune networks associated with varying severities of restrictive lung disease following COVID-19.

inSequio: A Programmable 3D CAD Application for Designing DNA Nanostructures

inSequio is a programmable 3D CAD tool for DNA nanostructure design that combines manual and programmatic editing, enhancing precision, scalability, and efficiency in DNA nanotechnology.

Spatiotemporal Clusters of ERK Activity Coordinate Cytokine-induced Inflammatory Responses in Human Airway Epithelial Cells

The paper shows pro-inflammatory cytokines induce SPREADs in human airway epithelial cells, correlating with barrier dysfunction, and that anti-inflammatory drugs suppress these SPREADs.

Broad-scale variation in human genetic diversity levels is predicted by purifying selection on coding and non-coding elements

The paper models purifying selection and selective sweeps in human genetic diversity using 1000 Genomes data, finding background selection explains most diversity variance.

PP1 promotes cyclin B destruction and the metaphase-anaphase transition by dephosphorylating CDC20

The paper shows PP1 dephosphorylates CDC20 to promote cyclin B destruction and the metaphase-anaphase transition in human cells.

Evaluating FAIR-Compliance Through an Objective, Automated, Community-Governed Framework

The paper introduces FAIR Evaluator, a tool to assess FAIRness of digital resources, and compares automated vs manual evaluations across repositories.

The ERBB network facilitates KRAS-driven lung tumorigenesis

This study shows that the ERBB network is required for KRAS-driven lung tumorigenesis and that inhibiting it enhances MEK inhibitor efficacy in treating such cancers.