J. Leon

Same data, different results? Machine learning approaches in bioacoustics

The paper evaluates machine learning methods for caller identity classification in mammalian vocalizations, finding Mel-frequency cepstral coefficients and random forests provide consistent results across datasets.

An interwoven network of transcription factors, with divergent influences from FoxP3, underlies Treg diversity

The paper defines the Treg regulatory network using single-cell chromatin accessibility and machine learning, revealing FoxP3's limited role in shaping Treg diversity.

MYC directly transactivates CR2/CD21, the receptor of the Epstein-Barr virus, and enhances the viral infection of Burkitt lymphoma cells

This paper identifies CR2/CD21 as a direct target of MYC and shows that MYC enhances EBV infection in Burkitt lymphoma cells.

Differential roles of beta-cell IP3R and RyR ER Ca2+ channels in ER stress-induced alterations of beta-cell Ca2+ homeostasis

This study investigates how ER stress affects IP3R and RyR Ca2+ channels in beta cells, showing RyR1 dysfunction contributes to Ca2+ dysregulation and apoptosis.

FoxP3 can fold into two distinct dimerization states with divergent functional implications for T cell homeostasis

This study shows FoxP3 can form two dimerization states, with head-to-head dimerization supporting function and swap-dimerization impairing it.

FoxP3 associates with enhancer-promoter loopsto regulate Treg-specific gene expression

This study identifies FoxP3's role in Treg cell identity by showing its association with enhancer-promoter loops and its correlation with heightened enhancer-promoter cross-talk.

A virus-specific monocyte inflammatory phenotype is induced by SARS-CoV2 at the immune-epithelial interface

The paper investigates SARS-CoV2-induced inflammatory responses in monocytes using in vitro co-cultures, identifying a virus-specific gene cluster distinct from other viruses.

Profound Treg perturbations correlate with COVID-19 severity

The paper identifies Treg cell perturbations in severe COVID-19 patients, showing increased FoxP3 levels and pro-inflammatory traits linked to disease severity.

A novel role of MNT as a negative regulator of REL and the NF-κB pathway

This study identifies MNT as a negative regulator of the NF-κB pathway by inhibiting REL translocation and repressing REL-target genes through a MNT-REL complex.

Single cell analysis of FOXP3 deficiencies in humans and mice unmasks intrinsic and extrinsic CD4+ T cell perturbations

The paper analyzes FOXP3 deficiencies in humans and mice using single-cell RNA-seq and flow cytometry to uncover intrinsic and extrinsic CD4+ T cell perturbations in IPEX syndrome.

Myc stimulates cell cycle progression through the activation of Cdk1 and phosphorylation of p27

The paper shows Myc activates Cdk1 to phosphorylate p27 at Thr187, promoting its degradation and cell cycle progression, with Cdk1 inhibition causing synthetic lethality with Myc.