CRISPR interference-based platform for multimodal genetic screens in human iPSC-derived neurons
R. Tian, M. A. Gachechiladze, C. H. Ludwig, M. T. Laurie, J. Y. Hong, D. Nathaniel, A. V. Prabhu, M. S. Fernandopulle, R. Patel, M. Abshari, M. E. Ward, M. Kampmann
This study develops a CRISPRi platform for genetic screens in human iPSC-derived neurons, identifying gene knockdown effects on survival, transcriptomics, and morphology.
bioRxiv · Jul 3, 2019Cell Biology