The H3.3 K36M oncohistone disrupts the establishment of epigenetic memory through loss of DNA methylation
J. Sinha, J. F. Nickels, A. R. Thurm, C. H. Ludwig, B. N. Archibald, M. M. Hinks, J. Wan, D. Fang, L. Bintu
This study shows that H3.3K36M mutation reduces epigenetic memory and promoter methylation by disrupting the conversion of H3K9me3 domains into DNA methylation.
bioRxiv · Oct 13, 2023 · PreprintCell Biology