Author

D. O. Morgan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Biophysics· 1 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell signaling & trafficking· 3 Assay:proteomics· 3 Organism:virus· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:fluorescence / live-cell microscopy· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

C. Carlson· 3 shared A. Adly· 2 shared M. Bi· 2 shared N. Hartooni· 2 shared Y. Cheng· 2 shared A. Ciling· 1 shared A. Jain· 1 shared A. M. Syed· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersMicrobiology

C. Carlson

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Assembly of SARS-CoV-2 ribonucleosomes by truncated N* variant of the nucleocapsid protein

A. Adly, M. Bi, C. Carlson, A. M. Syed, A. Ciling, J. Doudna, Y. Cheng, D. O. Morgan

This study shows that the truncated N* variant of SARS-CoV-2 nucleocapsid protein can assemble into vRNPs similar to full-length N, requiring the leucine-rich helix and inhibited by a phosphomimetic SR region.

bioRxiv · Aug 16, 2023Microbiology

Reconstitution of the SARS-CoV-2 ribonucleosome provides insights into genomic RNA packaging and regulation by phosphorylation

C. Carlson, A. Adly, M. Bi, Y. Cheng, D. O. Morgan

The paper reconstitutes the SARS-CoV-2 ribonucleosome in vitro and shows phosphorylation of the N protein disrupts vRNP assembly.

bioRxiv · May 23, 2022Biochemistry

Single-molecule analysis of specificity and multivalency in binding of short linear substrate motifs to the APC/C

N. Hartooni, J. Sung, A. Jain, D. O. Morgan

The paper develops a single-molecule assay to study SLiM binding to APC/C and finds distinct affinities and multivalency in substrate recognition.

bioRxiv · Sep 25, 2021Biophysics

Multisite phosphorylation by Cdk1 initiates delayed negative feedback to control mitotic transcription

J. Asfaha, M. Ord, C. Carlson, I. Faustova, M. Loog, D. O. Morgan

The paper shows that multisite phosphorylation of Ndd1 by Cdk1 initiates delayed negative feedback, controlling mitotic transcription through a pulse of gene expression.

bioRxiv · Feb 14, 2021Cell Biology

Phosphorylation modulates liquid-liquid phase separation of the SARS-CoV-2 N protein

C. R. Carlson, J. B. Asfaha, C. M. Ghent, C. J. Howard, N. Hartooni, D. O. Morgan

This study shows phosphorylation of SARS-CoV-2 N protein modulates its phase separation behavior, forming liquid-like droplets that may support viral genome processing.

bioRxiv · Jun 28, 2020Biochemistry

Polyanions provide selective control of APC/C interactions with the activator subunit

A. Mizrak, D. O. Morgan

The paper identifies polyanions as regulators of APC/C-activator interactions, showing they enhance dissociation and inhibit ubiquitination of low-affinity substrates while being blocked by high-affinity substrates.

bioRxiv · Jul 27, 2019Biochemistry