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4 papers
Recent·Most cited
T. Weiss, M. Kamalu, H. Shi, Z. Li, J. Amerasekera, Z. Zhong, B. A. Adler, M. Song, K. Vohra, G. Wirnowski, S. Chitkara, C. Ambrose, N. Steinmetz, A. Sridharan, D. Sahagun, , S. E. Jacobsen
This paper engineers a plant virus to deliver a compact CRISPR-Cas system for transgene-free germline editing in Arabidopsis.
bioRxiv · Jul 17, 2024 · PreprintPlant Biology
E. Armbruster, P. Rani, J. Lee, N. Klusch, J. Hutchings, L. Y. Hoffman, H. Buschkaemper, E. Enustun, B. Adler, K. Inlow, A. VanderWal, M. Y. Hoffman, D. Daksh, A. Aindow, A. Deep, , J. Pogliano
The paper shows that Chimalliviridae form a lipid membrane-bound EPI vesicle during early infection, which hosts transcription of the phage genome, and demonstrates the necessity of a second compartment, the phage nucleus, for genome replication.
bioRxiv · Sep 20, 2023 · PreprintCell Biology
A. Adly, M. Bi, C. Carlson, A. M. Syed, A. Ciling, J. Doudna, Y. Cheng, D. O. Morgan
This study shows that the truncated N* variant of SARS-CoV-2 nucleocapsid protein can assemble into vRNPs similar to full-length N, requiring the leucine-rich helix and inhibited by a phosphomimetic SR region.
bioRxiv · Aug 16, 2023Microbiology
E. J. Charles, S. E. Kim, G. J. Knott, D. Smock, J. Doudna, D. F. Savage
This paper engineers improved Cas13 effectors for targeted post-transcriptional regulation, showing efficient translational repression in bacteria and exon skipping in human cells.
bioRxiv · May 26, 2021 · PreprintBioengineering