Cell BiologybioRxiv
Thrombospondin-1 promotes fibro-adipogenic stromal expansion and contractile dysfunction of the diaphragm in obesity
E. D. Buras, M.-S. Woo, R. K. Verma…·T.-H. Chun
This study shows that THBS1 promotes diaphragm stromal expansion and contractile dysfunction in obesity by driving FAP proliferation and ECM changes.
DOI 10.1172/jci.insight.175047