Author

D. R. Thomas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:cryo-EM· 2 Approach:experimental assay· 2 Approach:microscopy & imaging analysis· 2 Research Focus:protein structure prediction· 2 Research Focus:cell type annotation· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

L. Joshua-Tor· 3 shared A. Axhemi· 1 shared A. Doymaz· 1 shared A. Hachani· 1 shared A. S. Hayes· 1 shared B. P. Howden· 1 shared B. Stillman· 1 shared C. J. Walsh· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersBiochemistry

L. Joshua-Tor

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A high-throughput cytotoxicity screening platform reveals agr-independent mutations in bacteraemia-associated Staphylococcus aureus that promote intracellular persistence

A. Hachani, S. G. Giulieri, R. Guerillot, C. J. Walsh, M. Herisse, Y. M. Soe, S. L. Baines, D. R. Thomas, S. D. Cheung, A. S. Hayes, H.-J. Cho, H. J. Newton, S. Pidot, R. C. Massey, B. P. Howden, T. P. Stinear

The paper develops a high-throughput platform to identify S. aureus mutations that enhance intracellular persistence and reduce cytotoxicity, revealing agr-independent pathoadaptive mutations.

bioRxiv · Dec 11, 2022Microbiology

A shape-shifting nuclease unravels structured RNA

K. Meze, A. Axhemi, D. R. Thomas, A. Doymaz, L. Joshua-Tor

The paper characterizes the degradation mechanism of Dis3L2 by analyzing its conformational changes during structured RNA processing.

bioRxiv · Nov 30, 2021Biochemistry

The dynamic nature of the human Origin Recognition Complex revealed through five cryoEM structures

M. J. Jaremko, K. F. On, D. R. Thomas, B. Stillman, L. Joshua-Tor

The paper reports five cryoEM structures of the human ORC, revealing its dynamic conformations and DNA-binding mechanisms.

bioRxiv · Aug 13, 2020Biochemistry

High-resolution cryo-EM structures of outbreak strain human norovirus shells reveal size variations

J. Jung, T. Grant, D. R. Thomas, C. W. Diehnelt, N. Grigorieff, L. Joshua-Tor

The paper presents high-resolution cryo-EM structures of multiple human norovirus strains, revealing size variations and structural polymorphism.

bioRxiv · Mar 16, 2019Biophysics