T. P. Stinear

This study investigates how human nasal epithelial cells respond to H. influenzae infection, revealing an initial inflammatory response followed by tolerance and reactivation of pro-inflammatory cytokines.

This study identifies the 3'UTR of vigR as critical for virulence in S. aureus, showing it regulates cell wall metabolism and interacts with mRNAs involved in virulence and antibiotic tolerance.

The paper investigates the transmission chain of Mycobacterium ulcerans between mosquitoes, possums, and humans in southeastern Australia, finding a significant association between M. ulcerans and Aedes notoscriptus mosquitoes.

This study uses structured surveys of possum excreta to predict human Buruli ulcer cases, showing improved predictive performance compared to null models.

The paper identifies a clpP SNP mutation in MRSA that reduces daptomycin binding and enables survival through rod-shaped morphology, contributing to antibiotic resistance.

The paper uses single-cell sequencing to compare innate immune responses to SARS-CoV-2 in nasal epithelial cells from adults and adolescents, finding age- and strain-dependent differences.

This study identifies the WalKR two-component system in Staphylococcus aureus as a polyfunctional regulator linking cell wall homeostasis with DNA replication and other essential processes.

The paper develops a high-throughput platform to identify S. aureus mutations that enhance intracellular persistence and reduce cytotoxicity, revealing agr-independent pathoadaptive mutations.

This paper develops and validates abritAMR, an ISO-accredited bioinformatics platform for detecting antimicrobial resistance genes with high accuracy and specificity.

The paper analyzes biosynthetic gene clusters in entomopathogenic nematode-symbiotic bacteria to identify conserved and unique natural products and their functional roles.

The paper uses long-read RNA sequencing to study polyadenylation and transcript usage changes in host cells during SARS-CoV-2 infection, identifying differential polyadenylation and transcript usage in infected cells.

The paper assesses toxicity variability among global MRSA lineages and identifies Agr mutations linked to reduced toxicity, highlighting the role of undefined genes in toxin regulation.

This study examines SARS-CoV-2 transcriptional and epi-transcriptional dynamics using long-read sequencing in human and primate infection models, revealing distinct patterns of sgRNA regulation and modification.

The paper validates a single-step, single-tube RT-LAMP assay for rapid SARS-CoV-2 detection with high specificity and sensitivity.

This study identifies ArcZ, an Hfq-dependent sRNA, as essential for small molecule production in entomopathogenic bacteria, revealing its broad regulatory role beyond secondary metabolites.

This study investigates how the gut microbiome changes in mice after colonization with vancomycin-resistant Enterococcus faecium, identifying metabolite associations linked to bacterial shifts.

The paper shows that BAT proteins from Burkholderia rhizoxinica prevent entrapment of endosymbionts in fungal hyphae, ensuring their survival and symbiosis.

The paper uses machine learning to predict adenylate-forming enzyme function and substrate specificity, revealing a β-lactone biosynthesis pathway in Nocardia.

This study evaluates the vaccine potential of M. ulcerans antigens Hsp18 and MUL_3720 in mice, finding high antibody titres but no significant protection against Buruli ulcer.

This study evaluates a prime-boost vaccine against Mycobacterium ulcerans in mice, finding that both the experimental ER vaccine and BCG provide significant protection through distinct immune profiles.

The paper identifies extensive diversity in type I restriction modification systems in Staphylococcus epidermidis compared to Staphylococcus aureus, enabling efficient genetic manipulation of clinically relevant strains.

This study examines the evolution of pSK1 family plasmids in MRSA ST239 isolates over 32 years, showing their role in enhancing chlorhexidine tolerance and gentamicin resistance.

The paper identifies zinc binding to the WalK histidine kinase's PAS domain as a negative regulator of the WalKR two-component system in Staphylococcus aureus.

The paper shows hospital Enterococcus faecium isolates from 2010 onward are 10-fold more tolerant to alcohol-based disinfectants than older isolates, leading to increased gastrointestinal colonization in mice.