Under or Over? Tracing Complex DNA Structures with High-Resolution Atomic Force Microscopy
E. P. Holmes, M. C. Gamill, J. I. Provan, L. Wiggins, R. Ruskova, S. Whittle, T. E. Catley, K. H. S. Main, N. Shephard, H. E. Bryant, N. S. Gilhooly, A. Gambus, D. Racko, S. D. Colloms, A. L. B. Pyne
This paper introduces a high-throughput AFM-based pipeline using deep learning to trace DNA topology, revealing new insights into DNA structures and their interactions.
bioRxiv · Jun 28, 2024Biophysics