Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
5 papers
Recent·Most cited
L. Gourmet, D. Ramazzotti, P. Mallick, S. Walker-Samuel, L. Zapata
This study identifies the temporal order of cancer hallmarks during tumorigenesis using mutation allele frequency and selective advantage across cancer and normal tissues.
bioRxiv · Jan 21, 2024 · PreprintCancer Biology
T. Heide, J. Househam, I. Spiteri, C. Lynn, G. D. Cresswell, M. Mossner, C. Kimberley, J. Fernandez-Mateos, B. Chen, L. Zapata, C. James, I. Barozzi, K. Chkhaidze, D. Nichol, A. Berner, , A. Sottoriva
This study examines the co-evolution of genome and epigenome in colorectal cancer using single-clone spatial multi-omic profiling, revealing epigenetic changes and their impact on mutation accumulation.
Nature · Oct 26, 2022Peer-reviewedCancer Biology
T. Heide, J. Househam, G. D. Cresswell, I. Spiteri, C. Lynn, C. Kimberley, M. Mossner, L. Zapata, C. Gabbutt, D. Ramazzotti, B. Chen, J. Fernandez-Mateos, C. James, F. Iorio, A. Berner, , A. Sottoriva
This study uses spatial multiomic data to assess the evolutionary impact of putative driver mutations in colorectal cancer, identifying both genetic and non-genetic factors influencing subclonal expansion.
bioRxiv · Jul 14, 2021 · PreprintCancer Biology
A. Lal, D. Ramazzotti, Z. Weng, K. Liu, J. Ford, A. Sidow
This study compares genomic features of BRCA1/BRCA2-mutated breast tumors with sporadic tumors, finding differences in mutation patterns, DNA methylation, and structural variation.
bioRxiv · May 19, 2019Cancer Biology
D. Ramazzotti, A. Lal, B. Wang, S. Batzoglou, A. Sidow
This paper introduces CIMLR, a multi-omic integration method that identifies cancer subtypes associated with survival differences across 36 cancer types.
bioRxiv · Oct 14, 2018Cancer Biology