Author

A. Berner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Research Focus:chromatin & epigenetic regulation· 3 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 3 Approach:statistical model· 3 Assay:whole-genome sequencing· 3 Assay:ATAC-seq· 2 Assay:bulk RNA-seq· 2

Frequent Co-Authors

A. Sottoriva· 3 shared A.-M. Baker· 3 shared B. Chen· 3 shared C. James· 3 shared C. Kimberley· 3 shared C. Lynn· 3 shared D. Nichol· 3 shared D. Shibata· 3 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

A. Sottoriva

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

G4-Ligand Conjugated Oligonucleotides Mediate Selective Binding and Stabilization of Individual G4 DNA Structures

A. Berner, R. N. Das, N. Bhuma, J. Golebiewska, A. Abrahamsson, M. Andreasson, N. Chaudhari, M. Doimo, P. P. Bose, K. Chand, R. Stromberg, S. Wanrooij, E. Chorell

The paper develops a method to selectively target and stabilize individual G4 DNA structures using ligand-conjugated oligonucleotides, demonstrating specificity without affecting off-target G4 formations.

bioRxiv · Sep 20, 2023 · PreprintBiochemistry

Phenotypic plasticity and genetic control in colorectal cancer evolution

J. Househam, T. Heide, G. D. Cresswell, C. Lynn, I. Spiteri, M. Mossner, C. Kimberley, C. Gabbutt, E. Lakatos, A. Berner, M. Schmidt, A.-M. Baker, J. Fernandez-Mateos, B. Chen, L. Zapata, , T. A. Graham

This study investigates phenotypic plasticity and genetic control in colorectal cancer by analyzing gene expression and genetic variation across multiple tumor regions.

Nature · Oct 26, 2022Peer-reviewedCancer Biology

The co-evolution of the genome and epigenome in colorectal cancer

T. Heide, J. Househam, I. Spiteri, C. Lynn, G. D. Cresswell, M. Mossner, C. Kimberley, J. Fernandez-Mateos, B. Chen, L. Zapata, C. James, I. Barozzi, K. Chkhaidze, D. Nichol, A. Berner, , A. Sottoriva

This study examines the co-evolution of genome and epigenome in colorectal cancer using single-clone spatial multi-omic profiling, revealing epigenetic changes and their impact on mutation accumulation.

Nature · Oct 26, 2022Peer-reviewedCancer Biology

Enhanced mitochondrial G-quadruplex formation impedes replication fork progression leading to mtDNA loss in human cells

M. Doimo, S. Abrahamsson, V. L'Hote, M. Ndi, R. N. Das, K. Aasumets, A. Berner, S. Goffart, J. L. O. Pohjoismäki, M. Davila, E. Chorell, S. Wanrooij

The paper shows that mitochondrial DNA replication stalling increases G-quadruplex formation, which blocks replication forks and leads to mtDNA loss in human cells.

bioRxiv · Jun 8, 2022Cell Biology

Assessment of the evolutionary consequence of putative driver mutations in colorectal cancer with spatial multiomic data

T. Heide, J. Househam, G. D. Cresswell, I. Spiteri, C. Lynn, C. Kimberley, M. Mossner, L. Zapata, C. Gabbutt, D. Ramazzotti, B. Chen, J. Fernandez-Mateos, C. James, F. Iorio, A. Berner, , A. Sottoriva

This study uses spatial multiomic data to assess the evolutionary impact of putative driver mutations in colorectal cancer, identifying both genetic and non-genetic factors influencing subclonal expansion.

bioRxiv · Jul 14, 2021 · PreprintCancer Biology