On the pH-dependence of α-synuclein amyloid polymorphism and the role of secondary nucleation in seed-based amyloid propagation
L. Frey, D. Ghosh, B. M. Qureshi, D. Rhyner, R. Guerrero-Ferreira, A. Pokharna, W. Kwiatkowski, T. Serdiuk, P. Picotti, R. Riek, J. Greenwald
This study investigates how pH affects α-synuclein fibril polymorphism and shows that secondary nucleation is not polymorph-specific, revealing new polymorphs at pH 7.0.
bioRxiv · Jun 25, 2023Biophysics