D. Ghosh

Electrostatic-driven Interactions Enhance Intratumoral Retention and Antitumor Efficacy of Immune Checkpoint Blockade Antibodies

Peptide-conjugated immune checkpoint blockade antibodies show enhanced antitumor efficacy through electrostatic interactions with tumor ECM, increasing CD8+ T cell infiltration and reducing regulatory T cells.

Applying machine learning to identify ionizable lipids for nanoparticle-mediated delivery of mRNA

This paper uses machine learning to predict the effectiveness of ionizable lipids for mRNA delivery, identifying the number of outside carbons as a key factor.

Intrinsic p53 Activation Restricts Gammaherpesvirus-Driven Germinal Center B Cell Expansion during Latency Establishment

This study shows that p53 activation restricts MHV68-driven GC B cell expansion during latency, with M2 and LMP1 triggering p53-dependent anti-proliferative responses.

Discovery of peptides for targeted delivery of mRNA lipid nanoparticles to cystic fibrosis lung epithelia

The paper identifies a peptide that enhances mRNA lipid nanoparticle delivery to CF lung epithelial cells, showing improved mRNA expression in vitro and in vivo.

Growth factor-induced desialylation for the fast control of endocytosis

The paper shows that growth factors induce rapid desialylation of cell surface glycoproteins, enabling reversible changes in glycan structure and function through galectin-mediated endocytosis.

Differential Carbonic Anhydrase Activities Control EBV-Induced B-Cell Transformation and Lytic Cycle Reactivation

This study shows that differential carbonic anhydrase activities regulate EBV-induced B-cell transformation and lytic cycle reactivation through transcriptional control by EBNA2 and BZLF1.

Spatial reorganization of Escherichia coli chromosome contextualizes triclosan stress-related genetic, epigenetic and transcriptome changes

The paper maps chromosomal interaction domains in E. coli under triclosan stress and links them to genetic, epigenetic, and transcriptome changes.

On the pH-dependence of α-synuclein amyloid polymorphism and the role of secondary nucleation in seed-based amyloid propagation

This study investigates how pH affects α-synuclein fibril polymorphism and shows that secondary nucleation is not polymorph-specific, revealing new polymorphs at pH 7.0.

The role of myosin contractility as a molecular determinant of traction force regulation

This study presents an analytical model of myosin contractility's role in traction force regulation, showing how varying molecular parameters leads to different stability states and matches experimental observations.

Atm loss does not radiosensitize a primary mouse model of Pten-deleted brainstem glioma

This study develops a mouse model of PTEN-mutated brainstem glioma and finds that ATM deletion does not enhance radiation efficacy in this model.

Negative Electrospray Supercharging Mechanisms of Oligonucleotide Single Strands and G-quadruplexes

This study investigates how negative electrospray supercharging of nucleic acids can be achieved while preserving native structures, finding that certain solvents enhance supercharging but may also cause unfolding.

How effective are frogs in regulating crop pest population in a natural multi-trophic system??

This study finds frogs do not effectively reduce crop pest abundance but negatively impact pest predator populations due to intraguild predation in agricultural systems.

Collation of indigenous and local knowledge as evidence base for herpetofauna conservation outside protected areas: Case study from an agricultural landscape in Eastern India

The paper documents how agricultural intensification affects herpetofauna through community knowledge surveys in Eastern India, finding a significant decline in amphibian and snake sightings in higher intensification areas.

A Drug-free, Self-destruction Strategy to Combat Bacterial Infections by Using the Intrinsically formed Magnetic Nanoparticles in Bacterial Pathogens

This paper demonstrates a drug-free strategy using magnetic nanoparticles formed by bacteria to combat infections, showing significant bacterial reduction with an alternating magnetic field.

Research productivity and collaboration of the NIH-funded HIV Vaccine Trials Network: a bibliometric analysis

This paper analyzes the scientific productivity and collaboration of the HIV Vaccine Trials Network (HVTN) over two decades using bibliometric methods, finding high-impact publications and increased collaboration.

Manufacturing Stable Bacteriophage Powders Using Thin Film Freeze-drying Technology

This paper demonstrates that thin film freeze-drying can produce stable bacteriophage powders suitable for inhalation therapy with minimal titer loss.

Molecular Elucidation of Pancreatic Elastase Inhibition by Baicalein

This study identifies baicalein as a potent pancreatic elastase inhibitor with lower IC50, cost, and improved safety compared to sivelestat, using in vitro and in silico methods.

Ecology and Function of Bacterial Lipases within the Gut Microbiome

This study identifies microbial lipases in the gut microbiomes of mice, pigs, and humans, revealing their role in triglyceride metabolism through glycerol utilization.

Climate change and the migration of a pastoralist people c.3500 cal. years BP inferred from palaeofire and lipid biomarker records in the montane Western Ghats, India

This paper infers the migration of the Todas to high elevations in the Western Ghats around 3500 cal. yr BP using palaeofire and lipid biomarker records.

p53 Controls Murine Gammaherpesvirus Latency and Prevents Infection-Associated IgH/c- Myc Translocations

This study shows that p53 restricts MHV68 latency establishment and prevents infection-associated genomic instability in mice.

Defining the DmsA Signal Sequence Interaction with DmsD And TatBC

The paper identifies key features of the DmsA signal sequence that mediate its interaction with DmsD and the TatBC complex, revealing structural and functional requirements for complex formation.

Expanding AHL Acylases Horizon - Insights From Structural Analysis of Choloylglycine Hydrolases From Shewanella lohica PV-4

This paper identifies SlCGH1 from Shewanella loihica PV-4 as a novel AHL acylase with unique structural and functional properties distinct from known CGHs and AHL acylases.

Hyperinsulinemia promotes HMGB1 release leading to inflammation induced systemic insulin resistance: An interplay between pancreatic beta-cell and peripheral organs

This study shows hyperinsulinemia promotes inflammation via HMGB1 and TLR4 signaling, leading to systemic insulin resistance, and demonstrates naltrexone's protective effects.

Identification of peptide coatings that enhance diffusive transport of nanoparticles through the tumor microenvironment

The paper identifies a peptide coating that enhances nanoparticle diffusion through the tumor microenvironment by screening phage libraries and testing transport in vitro and ex vivo.

A combinatorial biomolecular strategy to identify peptides for improved transport across the sputum of cystic fibrosis patients and the underlying epithelia

The paper identifies peptides that enhance drug delivery through mucus and epithelial barriers in CF patients using phage libraries and sequencing.

M13 phage display to identify a permeating peptide against hyperconcentrated mucin

The paper uses M13 phage display to identify a neutral, hydrophilic peptide that enhances permeation through hyperconcentrated mucin.

Intracellular nanoparticle delivery by oncogenic KRAS-mediated macropinocytosis

This paper demonstrates that mutant KRAS-driven macropinocytosis can be exploited to deliver albumin nanoparticles into cancer cells, showing increased uptake compared to wild-type KRAS cells.

Radtools: R utilities for smooth navigation of medical image data

Radtools simplifies extraction and navigation of metadata from medical image files like DICOM and NIfTI in R.

Development and Application of a High-Content Virion Display Human GPCR Array

The paper develops a high-content Virion Display (VirD) array of human GPCRs to profile their biochemical activities and identifies potential drug targets.