Discovery of novel potent, cell-permeable inhibitors of P. falciparum cGMP-dependent protein kinase.
R. R. Y. Bheemanaboina, M. L. Gonzalez, S. U. Mahmood, T. Eck, T. Kreiss, M. L. de Souza, S. O. Aylor, A. Roth, P. Lee, B. S. Pybus, P. Bhanot, D. J. Colussi, W. E. Childers, J. Gordon, J. J. Siekierka, D. Rotella
The paper reports the discovery and optimization of novel PfPKG inhibitors with good potency, low hERG activity, and anti-parasitic activity.
bioRxiv · Aug 24, 2021 · PreprintPharmacology & Toxicology