A. Roth

The spatially resolved tumor microenvironment predicts treatment outcome in relapsed/refractory Hodgkin lymphoma

The paper develops a prognostic model using spatially resolved tumor microenvironment features to predict treatment outcomes in relapsed/refractory Hodgkin lymphoma.

Single cell preparations of Mycobacterium tuberculosis damage the mycobacterial envelope and disrupt macrophage interactions

This study shows that common methods to prepare Mycobacterium tuberculosis for experiments damage the bacterial envelope, alter macrophage responses, and affect bacterial survival.

The dominance of coinfecting parasites' indirect effects on host traits

This paper investigates how indirect genetic effects (IGEs) from coinfecting parasites influence host traits and shows that dominance of these effects can alter parasite evolution.

Discovery of imidazole-based inhibitors of P. falciparum cGMP-dependent protein kinase

The paper identifies imidazole-based inhibitors of PfPKG with good potency and low hERG activity against multiple Plasmodium species.

Discovery of novel potent, cell-permeable inhibitors of P. falciparum cGMP-dependent protein kinase.

The paper reports the discovery and optimization of novel PfPKG inhibitors with good potency, low hERG activity, and anti-parasitic activity.

The Imaging and Molecular Annotation of Xenografts and Tumours (IMAXT) High Throughput Data and Analysis Infrastructure

The paper presents an infrastructure for high-throughput data and analysis of tumour and xenograft samples using multimodal imaging and molecular annotation.

SILAKin: A novel high throughput SILAC and mass spectrometry-based assay to identify the substratome of kinases secreted by pathogens

SILAkin identifies kinase substrates using a combination of phosphatase treatment, pulse heating, IVKA, and SILAC-based MS, revealing 225 host substrates phosphorylated by pathogen-excreted kinases.

LL-37 fights SARS-CoV-2: The Vitamin D-Inducible Peptide LL-37 Inhibits Binding of SARS-CoV-2 Spike Protein to its Cellular Receptor Angiotensin Converting Enzyme 2 In Vitro

This study shows LL-37, a vitamin D-induced peptide, binds to SARS-CoV-2 spike protein and inhibits its interaction with ACE2, potentially preventing viral entry.

Biochemical Validation of a Fourth Guanidine Riboswitch Class in Bacteria

The paper identifies and validates a fourth guanidine riboswitch class in bacteria, demonstrating its novel aptamer and expression platform for ligand-dependent gene activation.

Polypeptide collapse modulation and folding stimulation by GroEL-ES

This study shows GroEL-ES enhances polypeptide collapse, directly stimulating folding by pulling chains into its cavity and promoting compaction and folding transitions.

Predation drives specialized host plant associations in preadapted milkweed bugs (Heteroptera: Lygaeinae)

The paper shows that predation pressure drives host plant specialization in milkweed bugs by selecting for toxin sequestration abilities, even when new toxins are not exploited.

Safety, pharmacokinetics, and liver-stage Plasmodium cynomolgi effect of high-dose ivermectin and chloroquine in Rhesus Macaques

This study evaluates the safety, pharmacokinetics, and efficacy of high-dose ivermectin and chloroquine in Rhesus macaques against Plasmodium cynomolgi liver stages, finding no inhibition of blood-stage parasitemia but good tolerability.

Substrate binding modulates the conformational kinetics of the secondary multidrug transporter LmrP

This study uses smFRET to show substrate binding modulates conformational kinetics of LmrP, revealing substrate-dependent structural changes in MFS transporters.

E-scape: Interactive visualization of single cell phylogenetics and spatio-temporal evolution in cancer

E-scape provides an interactive visualization tool for analyzing cancer clonal dynamics and spatio-temporal evolution using integrated mutation, phylogenetic, and imaging data.