Integrating multiple omics levels using the human protein complexome as a framework, a multi-omics study of inborn errors of metabolism
M. Guharoy, I. Adant, M. Bird, A. J. Pedrayes, A. Botzki, J. Dehairs, S. Derveaux, S. Devos, G. Goeminne, F. Impens, R. Janky, R. Maes, T. M. Maia, W. Meersseman, D. Rymen, , B. Ghesquiere
This study integrates proteomics, transcriptomics, and metabolomics data from IEM patients to identify perturbed protein complexes and pathways, highlighting mitochondrial oxidative phosphorylation and histone acetylation dysregulation.
bioRxiv · Dec 30, 2023 · PreprintBiochemistry