Author

A. Botzki

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Approach:machine learning (classical)· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

A. J. Pedrayes· 1 shared A. Smet· 1 shared B. Ghesquiere· 1 shared B. Lambrecht· 1 shared B. Wiernicki· 1 shared D. Cassiman· 1 shared D. Rymen· 1 shared D. Van Haver· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperBiochemistry

A. J. Pedrayes

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

The antigenic landscape of human influenza N2 neuraminidases from 2009 until 2017

J. P. Catani, A. Smet, T. Ysenbaert, M. Vuylsteke, G. Bottu, J. Mathys, A. Botzki, G. Cortes-Garcia, T. Strudnell, R. Gomila, J. Hamberger, J. Catalan, I. Ustyugova, T. Farrell, S. Stegalkina, , T. U. Vogel

This study analyzes the antigenic diversity of N2 neuraminidases from 2009-2017 H3N2 influenza viruses and develops a machine learning method to predict the impact of mutations on NA inhibition.

eLife · May 28, 2024Peer-reviewedImmunology

Integrating multiple omics levels using the human protein complexome as a framework, a multi-omics study of inborn errors of metabolism

M. Guharoy, I. Adant, M. Bird, A. J. Pedrayes, A. Botzki, J. Dehairs, S. Derveaux, S. Devos, G. Goeminne, F. Impens, R. Janky, R. Maes, T. M. Maia, W. Meersseman, D. Rymen, , B. Ghesquiere

This study integrates proteomics, transcriptomics, and metabolomics data from IEM patients to identify perturbed protein complexes and pathways, highlighting mitochondrial oxidative phosphorylation and histone acetylation dysregulation.

bioRxiv · Dec 30, 2023 · PreprintBiochemistry

ADAR1 interaction with Z-RNA promotes editing of endogenous double-stranded RNA and prevents MDA5-dependent immune activation.

R. de Reuver, E. Dierick, B. Wiernicki, K. Staes, L. Seys, E. De Meester, T. Muyldermans, A. Botzki, B. Lambrecht, F. Van Nieuwerburgh, P. Vandenabeele, J. Maelfait

This study shows that ADAR1's interaction with Z-RNA reduces A-to-I editing of self-dsRNA, leading to MDA5-dependent immune activation and AGS in mutant cells and mice.

bioRxiv · Dec 4, 2020Immunology