Author

D. Sieme

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

C. Griesinger· 2 shared J. Wienands· 2 shared S. Becker· 2 shared F. Dar· 1 shared J. Maier· 1 shared L. E. Wong· 1 shared M. Engelke· 1 shared N. Rezaei-Ghaleh· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 22 mutual co-author links

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2 shared papersBiophysics

C. Griesinger

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2 papers

Recent·Most cited

Autoinhibition in the Signal Transducer CIN85 Modulates B Cell Activation

D. Sieme, M. Engelke, N. Rezaei-Ghaleh, S. Becker, J. Wienands, C. Griesinger

This study identifies an intramolecular SH3:PRM interaction in CIN85 that modulates its valency and phase separation, affecting B cell activation.

bioRxiv · Jul 31, 2023Biophysics

Quantitative description of the phase separation behavior of the multivalent SLP65-CIN85 complex

J. Maier, D. Sieme, L. E. Wong, F. Dar, J. Wienands, S. Becker, C. Griesinger

The paper quantifies SH3-PRM interactions in SLP65/CIN85 complexes and models their phase separation behavior using LASSI, revealing an intramolecular interaction.

bioRxiv · Jul 31, 2023Biophysics