Interacting evolutionary pressures drive mutation dynamics and health outcomes in aging blood
K. Skead, A. Ang Houle, S. Abelson, M. Agbessi, V. Bruat, B. Lin, D. Soave, L. Shlush, S. Wright, J. Dick, Q. Morris, P. Awadalla
The paper models positive and negative selection in blood cells to explain why some people with ARCH do not progress to AML, finding that passenger mutation burden influences clonal dominance.
Nature Communications · Aug 13, 2021Peer-reviewedCancer Biology