B. Lin

An organoid co-culture model for probing systemic anti-tumor immunity in lung cancer

The paper develops a co-culture model of lung cancer organoids and peripheral blood mononuclear cells to study systemic anti-tumor immunity and predict immunotherapy outcomes.

FLASH radiotherapy using high-energy X-rays: validation of the FLASH effect triggered by a compact single high-energy X-ray source device

This study validates the FLASH effect using a compact high-energy X-ray source in mice, showing protective effects on normal tissues but no significant tumor response differences between FLASH and conventional radiotherapy.

Airway basal stem cells are necessary for the maintenance of functional intraepithelial airway macrophages.

This study shows that airway basal stem cells maintain intraepithelial airway macrophages via Notch signaling, enabling localized allergic inflammation in the trachea but not distal lung tissues.

Identification and classification of the genomes of novel Microviruses in a poultry slaughterhouse

This study identifies 98 novel microvirus genomes from a poultry slaughterhouse, classifies them into 6 new subfamilies and 3 higher-level units, and expands their known host range.

A deep lung cell atlas reveals cytokine-mediated lineage switching of a rare cell progenitor of the human airway epithelium

This study identifies a rare progenitor cell population in the human airway that can differentiate into ionocytes or tuft cells, and shows cytokines can shift their lineage towards tuft cells in asthma and CF.

Single Cell Transcriptomes, Lineage, and Differentiation of Functional Airway Microfold Cells

This study identifies and characterizes airway Microfold (M) cells using single-cell transcriptomics, revealing their lineage, differentiation pathways, and functional role in antigen sampling via CR2-dependent endocytosis.

Bayesian Approach Enabled Objective Comparison of Multiple Human iPSC-derived Cardiomyocytes' Proarrhythmia Sensitivities.

The paper uses Bayesian statistics to objectively compare proarrhythmic sensitivities of five human iPSC-derived cardiomyocyte lines to ten compounds, identifying differences in calcium transient responses.

Assessing risks and mechanisms of idiosyncratic drug toxicity by fingerprints of cell signaling responses.

The paper assesses idiosyncratic drug toxicity by analyzing cell signaling responses, finding that drugs with smaller safety margins are more likely to cause liver injury.

Illuminating kinase inhibitors biology by cell signaling profiling.

This paper introduces a method to evaluate kinase inhibitors by profiling transcription factor activity, revealing consensus signatures that indicate on-target biological effects.

Regnase-1 deficiency restrains Klebsiella pneumoniae infection by regulation of a Type I interferon response

This study shows that Regnase-1 deficiency increases resistance to Klebsiella pneumoniae infection by enhancing Type I interferon responses, despite not affecting bacterial clearance or pro-inflammatory cytokine expression.

Multi-omics analysis for potential inflammation-related genes involved in tumor immune evasion via extended application of epigenetic data

The paper identifies STAT2 as a regulator of PD-L1 expression through multi-omics analysis and experimental validation, linking it to tumor immune evasion.

A phosphoregulated RhoGEF feedback loop tunes cortical flow driven amoeboid migration in vivo

This study identifies a phosphoregulated RhoGEF2 feedback loop that tunes cortical flow and migration in Drosophila primordial germ cells during in vivo homing.

Structure-activity relationships of B.1.617 and other SARS-CoV-2 spike variants

This study reports cryo-EM structures of SARS-CoV-2 spike variants and finds mutations alter conformation and glycan shield, enhance ACE2 binding, but are neutralized by three antibodies.

Interacting evolutionary pressures drive mutation dynamics and health outcomes in aging blood

The paper models positive and negative selection in blood cells to explain why some people with ARCH do not progress to AML, finding that passenger mutation burden influences clonal dominance.

Inhibition of cancer cells in culture. The effects of treatment with ketone bodies and/or rapamycin treatment

This study shows that ketone bodies and rapamycin inhibit cancer cell proliferation in culture, with additive effects, suggesting potential for reducing drug doses when combined.

Microtubule inhibitors identified through non-biased screening enhance DNA transfection efficiency by delaying p62-dependent ubiquitin recruitment

Injectable Progranulin-derivative Atsttrin loaded Protein Engineered Gels for Post Traumatic Osteoarthritis

This paper develops a protein-based gel that delivers Atsttrin to prevent post-traumatic osteoarthritis in a rabbit model.

Discovery of novel ID2 antagonists from pharmacophore-based virtual screening as potential therapeutics for glioma

This study identifies AK-778-XXMU as a potent ID2 antagonist with potential as a glioma therapeutic through pharmacophore-based virtual screening and experimental validation.

NOMA: a high-throughput microchip for robust, sequential measurements of secretions from the same single-cells

The paper introduces a microchip called NOMA that enables sequential tracking of secretions from the same single cells with high retention efficiency.

First demonstration of the FLASH effect with ultrahigh dose-rate high-energy X-rays

This paper demonstrates the first use of high-energy X-rays in FLASH radiotherapy, showing effective tumor control and tissue protection in mice.

A novel RyR1 inhibitor prevents and rescues sudden death in a mouse model of malignant hyperthermia and heat stroke

This study introduces a novel RyR1 inhibitor that prevents and rescues MH and heat stroke in mouse models, offering improved solubility and clearance compared to dantrolene.

The Nucleocapsid Protein of SARS-CoV-2 Abolished Pluripotency in Human Induced Pluripotent Stem Cells

This study shows that SARS-CoV-2 nucleocapsid protein reduces pluripotency in human iPSCs, causing them to lose differentiation ability and adopt fibroblast-like morphology.

Angiotensin II induces apoptosis in human induced pluripotent stem cell-derived cardiomyocytes

This study shows that high concentrations of angiotensin II induce apoptosis in human iPSC-derived cardiomyocytes after long-term exposure.

Machine learning reveals heterogeneous responses to FAK, Rac, Rho, and Cdc42 inhibition on vascular smooth muscle cell spheroid formation and morphology

This study uses HETEROID to analyze how FAK, Rac, Rho, and Cdc42 inhibitors affect VSMC spheroid formation and morphology, revealing pathway-specific responses.

Large particle fluorescence-activated cell sorting enables high quality single cell RNA-sequencing and functional analysis of adult cardiomyocytes

This study demonstrates that large-particle fluorescence-activated cell sorting (LP-FACS) improves the isolation of viable adult cardiomyocytes, enabling high-quality single-cell RNA sequencing and functional analysis.

Multiplexed Profiling of Single-cell Extracellular Vesicles Secretion

This paper develops a platform to multiplex profile single-cell EV secretion, revealing heterogeneity in EV phenotypes and secretion patterns in OSCC cells.