S. Wright

Isoflurane preferentially modulates synaptic responses to corticocortical stimulation over thalamocortical stimulation

This study examines how isoflurane affects synaptic responses to cortico-cortical and thalamocortical stimulation in the auditory cortex, finding greater suppression of cortico-cortical responses.

Discovery of a novel inhibitor of macropinocytosis with antiviral activity

This study identifies virapinib, a novel inhibitor of macropinocytosis that blocks viral entry by SARS-CoV-2, Monkeypox virus, and TBEV without host cell toxicity.

The microbial community dynamics of cocaine sensitization in two behaviorally divergent strains of collaborative cross mice

This study examines how gut microbiome composition and changes in response to cocaine affect behavioral sensitization in two divergent Collaborative Cross mouse strains.

Genetic evidence that uptake of the fluorescent analog 2NBDG occurs independently of known glucose transporters

The paper shows that 2NBDG uptake in cells occurs independently of known glucose transporters, suggesting a separate mechanism for its import.

Developmental and environmental plasticity in opsin gene expression in Lake Victoria cichlid fish

This study examines how opsin gene expression in Lake Victoria cichlid fish changes with development and environmental light conditions, finding plastic responses and parental effects in hybrids.

Interacting evolutionary pressures drive mutation dynamics and health outcomes in aging blood

The paper models positive and negative selection in blood cells to explain why some people with ARCH do not progress to AML, finding that passenger mutation burden influences clonal dominance.

Substrate, temperature, and geographical patterns among nearly 2,000 natural yeast isolates

The paper analyzes nearly 2,000 natural yeast isolates to identify geographic, substrate, and temperature patterns among yeast taxa.

Phenotypic plasticity, population structure and adaptation in a young weed species with a worldwide distribution

This study investigates the roles of phenotypic plasticity and genetic adaptation in the rapid global spread of the weed Capsella bursa-pastoris through common garden experiments.

The genetic architecture and genomic context of glyphosate resistance in Amaranthus tuberculatus

This study identifies the genetic architecture of glyphosate resistance in Amaranthus tuberculatus, revealing polygenic resistance mechanisms beyond target-site mutations.

Barbadin selectively modulates FPR2-mediated neutrophil functions independent of receptor endocytosis

This study shows Barbadin enhances FPR2-mediated ROS production in neutrophils without affecting receptor endocytosis, suggesting AP2 plays a role in ROS release.

Functional Interrogation of HOXA9 Regulome in MLLr Leukemia via Reporter-based CRISPR/Cas9 screen

The paper uses a HOXA9-mCherry reporter and CRISPR/Cas9 screens to identify USF1/USF2 as regulators of HOXA9 in MLLr leukemia, showing their role in leukemia cell proliferation.

The evolutionary forces shaping cis and trans regulation of gene expression within a population of outcrossing plants.

The paper identifies trans-eQTLs in Capsella grandiflora and finds they are under stronger negative selection than cis-eQTLs, though some trans-eQTLs persist at intermediate frequencies.

The effects of losing sex on the molecular evolution of plant defense

The paper tests if loss of sex in Oenothera plants affects molecular evolution of defense genes by comparing selection patterns in sexual and asexual species.

Population genomics of the facultatively asexual duckweed Spirodela polyrhiza

The paper examines genetic diversity in the asexually reproducing duckweed Spirodela polyrhiza and finds low diversity with weak purifying selection, suggesting rare but not negligible sex at the population level.

Long-term balancing selection drives evolution of immunity genes in Capsella

The paper shows that balancing selection maintains genetic diversity at immunity genes across Capsella species after population bottlenecks.

Coalescence and linkage disequilibrium in facultatively sexual diploids

This study models LD decay in facultatively sexual diploids, showing that meiotic recombination scales with sex probability, while mitotic gene conversion is critical under rare sex.

CRISPR-Cas9 ribonucleoprotein-mediated co-editing and counterselection in the rice blast fungus

This paper develops a plasmid-free CRISPR-Cas9 method for efficient gene editing in the rice blast fungus, enabling precise mutations and isogenic strain creation.