Optogenetic manipulation of cGMP highlights PDE5 as the predominant cGMP-hydrolyzing PDE in megakaryocytes
Y. Zhang, P. Benz, D. Stehle, S. Yang, H. Kurz, S. Feil, G. Nagel, R. Feil, S. Gao, M. Bender
The paper uses optogenetics to manipulate cGMP levels in megakaryocytes and identifies PDE5 as the main enzyme regulating cGMP.
bioRxiv · Nov 12, 2021 · PreprintCell Biology