In utero delivery of miRNA induces epigenetic alterations and corrects pulmonary pathology in congenital diaphragmatic hernia
D. Stitelman, S. Ullrich, N. Yung, T. Bauer-Pisani, N. Maassel, M. E. Guerra, M. Freedman-Weiss, S. Ahle, A. Ricciardi, M. Sauler, W. M. Saltzman, A. Piotrowski-Daspit
This paper shows that delivering miR200b via nanoparticles in utero improves lung development in a rat model of congenital diaphragmatic hernia by altering the TGFβ pathway.
bioRxiv · Feb 27, 2022Bioengineering