S. Ullrich

Targeting the paralog protein for degradation accounts for the opposite roles of NRBP1 and NRBP2 in regulating LINE1 retrotransposition

The paper shows NRBP1 and NRBP2 oppositely regulate LINE1 retrotransposition through proteasome-mediated degradation of NRBP1 by NRBP2, with NRBP2's regulatory function evolving later.

Microscopy analysis of delayed co-transcriptional splicing in highly expressed thyroglobulin gene

The paper uses microscopy to study delayed co-transcriptional splicing in the highly expressed thyroglobulin gene, finding a delay in splicing downstream of transcribed introns.

Phage-Encoded Bismuth Bicycles: Instant Access to Targeted Bioactive Peptides

This paper introduces a method to create bicyclic peptides using bismuth and arsenic in phage display, showing improved binding affinity over linear peptides.

The highly and perpetually upregulated thyroglobulin gene is a hallmark of functional thyrocytes

The paper identifies thyroglobulin gene (Tg) as a permanently upregulated gene in thyrocytes across vertebrates, providing insights into mechanisms of sustained transcriptional activation.

Predicting antiviral resistance mutations in SARS-CoV-2 main protease with computational and experimental screening

This study identifies resistance mutations in SARS-CoV-2 main protease to the drug Nirmatrelvir using computational screening and experimental validation.

In utero delivery of miRNA induces epigenetic alterations and corrects pulmonary pathology in congenital diaphragmatic hernia

This paper shows that delivering miR200b via nanoparticles in utero improves lung development in a rat model of congenital diaphragmatic hernia by altering the TGFβ pathway.

Main protease mutants of SARS-CoV-2 variants remain susceptible to nirmatrelvir (PF-07321332)

This study shows that nirmatrelvir remains effective against Mpro variants from current SARS-CoV-2 lineages.

Discovery of Antiviral Cyclic Peptides Targeting the Main Protease of SARS-CoV-2 via mRNA Display

This study identifies cyclic peptides targeting SARS-CoV-2 main protease using mRNA display, showing antiviral activity in vitro.

Microscopy-based assay for semi-quantitative detection of SARS-CoV-2 specific antibodies in human sera

The paper develops a semi-quantitative microscopy-based assay to detect SARS-CoV-2 specific antibodies in human sera, providing a sensitive and specific method for serological analysis.

SPATIAL ORGANIZATION OF TRANSCRIBED EUKARYOTIC GENES

This study investigates how transcription shapes genome spatial organization by analyzing long highly expressed genes and demonstrating the formation of transcription loops with polymerases and nascent RNAs.