M. Sauler

Spatiotemporal coordination of stem cell behavior following alveolar injury

This study tracks alveolar type 2 stem cell behavior after injury using live imaging and identifies distinct motility states and their regulation.

Lung spatial profiling reveals a T cell signature in COPD patients with fatal SARS-CoV-2 infection

The paper uses spatial transcriptomic and proteomic profiling to analyze lung tissues from COPD patients who died of COVID-19, revealing increased T-lymphocytes and altered immune responses.

In utero delivery of miRNA induces epigenetic alterations and corrects pulmonary pathology in congenital diaphragmatic hernia

This paper shows that delivering miR200b via nanoparticles in utero improves lung development in a rat model of congenital diaphragmatic hernia by altering the TGFβ pathway.

Integrated Single Cell Atlas of Endothelial Cells of the Human Lung

The paper reanalyzes six scRNA-seq datasets to create a comprehensive reference atlas of human lung endothelial cells, identifying new subpopulations and confirming their conservation in mice.

Decreased miR-24-3p potentiates DNA damage responses and increases susceptibility to COPD

The paper identifies miR-24-3p as a regulator of DNA damage responses and COPD susceptibility, showing its suppression in COPD and its role in modulating apoptosis and DNA repair.