D. Stroka

Released Bacterial ATP Shapes Local and Systemic Inflammation during Abdominal Sepsis

This study investigates how bacteria release ATP during sepsis and shows that bacterial ATP suppresses local immune responses and exacerbates systemic inflammation through outer membrane vesicles.

Germline cis variant determines epigenetic regulation of the anti-cancer drug metabolism gene dihydropyrimidine dehydrogenase (DPYD)

The paper identifies a germline variant that regulates DPYD gene expression through an enhancer, affecting 5-FU drug resistance.

Primary infection by E. multilocularis induces distinct patterns of crosstalk between hepatic regulatory T and natural killer T cells in mice

The paper uses single-cell RNA sequencing to analyze T cell responses in mice infected with E. multilocularis, revealing distinct interactions between regulatory T and natural killer T cells that influence disease progression.

The human vault RNA enhances tumorigenesis and chemoresistance through the lysosome

This study shows that vtRNA1-1 promotes tumorigenesis and chemoresistance by regulating lysosomal function through the ERK1/2-TFEB pathway.

Compartmentalization of intestinal bacteria by hepatic ILC3s prevents infections after surgery

The paper shows that intestinal bacteria cause surgical infections and that hepatic ILC3s prevent their translocation, highlighting the role of controlled commensalism in preventing post-surgical infections.

Connexin-43 dependent ATP release mediates macrophage activation during peritonitis

This study shows that Connexin-43-mediated ATP release from macrophages via TLR-2 and -4 agonists promotes sepsis severity, and inhibiting this pathway improves survival in peritonitis.