QTQTN motif upstream of the furin-cleavage site plays key role in SARS-CoV-2 infection and pathogenesis.
M. N. Vu, K. Lokugamage, J. A. Plante, D. Scharton, B. A. Johnson, S. Sotcheff, D. Swetnam, C. Schindewolf, R. E. Alvarado, P. A. Crocquet-Valdes, K. Debbink, S. Weaver, D. H. Walker, A. L. Routh, K. S. Plante, V. D. Menachery
This study shows that deleting the QTQTN motif reduces SARS-CoV-2 replication and disease by affecting spike processing and glycosylation.
bioRxiv · Dec 15, 2021Microbiology