C. Schindewolf

Loss-of-function mutation in Omicron variants reduces spike protein expression and attenuates SARS-CoV-2 infection

This study identifies the N679K mutation in Omicron variants as reducing spike protein expression and attenuating SARS-CoV-2 infection, while showing a replication advantage in the upper airway.

SARS-CoV-2 Uses Nonstructural Protein 16 to Evade Restriction by IFIT1 and IFIT3

This paper shows that SARS-CoV-2's NSP16 protein helps evade immune detection by methylating viral mRNA, and disrupting this function reduces viral replication and disease in hamsters.

Development of highly potent non-covalent inhibitors of SARS-CoV-2 3CLpro

This study develops a potent non-covalent inhibitor of SARS-CoV-2 3CLpro, showing effective antiviral activity in human cells and animal models.

QTQTN motif upstream of the furin-cleavage site plays key role in SARS-CoV-2 infection and pathogenesis.

This study shows that deleting the QTQTN motif reduces SARS-CoV-2 replication and disease by affecting spike processing and glycosylation.

Nucleocapsid mutations in SARS-CoV-2 augment replication and pathogenesis.

This study shows that mutations in the SARS-CoV-2 nucleocapsid protein enhance viral replication and pathogenesis by increasing phosphorylation and resisting kinase inhibition.

Delta spike P681R mutation enhances SARS-CoV-2 fitness over Alpha variant

This study identifies the P681R mutation in the Delta variant's spike protein as critical for enhanced viral replication compared to the Alpha variant through increased furin cleavage of the spike protein.

Mouse Adapted SARS-CoV-2 protects animals from lethal SARS-CoV challenge

This study creates a mouse-adapted SARS-CoV-2 strain that protects mice from lethal SARS-CoV challenge, demonstrating cross-strain immunity.

The N501Y spike substitution enhances SARS-CoV-2 transmission

The paper shows the N501Y spike mutation in SARS-CoV-2 enhances viral transmission in hamsters and human airway cells by increasing receptor binding affinity.

Type I interferon susceptibility distinguishes SARS-CoV-2 from SARS-CoV.

This study compares the sensitivity of SARS-CoV-2 and SARS-CoV to type I interferon, finding SARS-CoV-2 is more susceptible to IFN-I treatment.

Furin Cleavage Site Is Key to SARS-CoV-2 Pathogenesis

This study shows that removing the furin cleavage site from SARS-CoV-2 increases replication in Vero cells but reduces replication in respiratory cells and pathogenesis in hamsters, while also decreasing neutralization susceptibility.

Isolation and characterization of SARS-CoV-2 from the first US COVID-19 patient

The paper isolates and characterizes SARS-CoV-2 from the first US COVID-19 patient, showing high replication in Vero cells and depositing the strain for public use.