Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
9 papers
Recent·Most cited
S. Desai, Y. Zhou, R. Dilawari, A. L. Routh, V. Popov, L. J. Kenney
This study identifies RpoS as a key regulator of Salmonella Typhi biofilm formation and persistence in the gall bladder, revealing a CsgD-independent mechanism.
bioRxiv · Oct 26, 2023 · PreprintMicrobiology
M. N. Vu, R. E. Alvarado, D. R. Morris, K. G. Lokugamage, Y. Zhou, A. L. Morgan, L. K. Estes, A. M. McLeland, C. Schindewolf, J. A. Plante, Y. P. Ahearn, W. M. Meyers, J. T. Murray, S. Weaver, D. H. Walker, , V. D. Menachery
This study identifies the N679K mutation in Omicron variants as reducing spike protein expression and attenuating SARS-CoV-2 infection, while showing a replication advantage in the upper airway.
bioRxiv · Apr 17, 2023Microbiology
C. Schindewolf, K. Lokugamage, M. Vu, B. A. Johnson, D. Scharton, J. A. Plante, B. K. Kalveram, P. A. Crocquet-Valdes, S. L. Sotcheff, E. Jaworski, R. E. Alvarado, K. Debbink, M. D. Daugherty, S. Weaver, A. L. Routh, , V. D. Menachery
This paper shows that SARS-CoV-2's NSP16 protein helps evade immune detection by methylating viral mRNA, and disrupting this function reduces viral replication and disease in hamsters.
bioRxiv · Sep 26, 2022Microbiology
B. A. Johnson, Y. Zhou, K. G. Lokugamage, M. N. Vu, N. E. Bopp, P. A. Crocquet-Valdes, B. Kalveram, C. Schindewolf, Y. Liu, D. Scharton, J. A. Plante, X. Xie, P. Aguilar, S. Weaver, P.-Y. Shi, , V. D. Menachery
This study shows that mutations in the SARS-CoV-2 nucleocapsid protein enhance viral replication and pathogenesis by increasing phosphorylation and resisting kinase inhibition.
PLOS Pathogens · Jun 21, 2022Peer-reviewedMicrobiology
M. N. Vu, K. Lokugamage, J. A. Plante, D. Scharton, B. A. Johnson, S. Sotcheff, D. Swetnam, C. Schindewolf, R. E. Alvarado, P. A. Crocquet-Valdes, K. Debbink, S. Weaver, D. H. Walker, A. L. Routh, K. S. Plante, V. D. Menachery
This study shows that deleting the QTQTN motif reduces SARS-CoV-2 replication and disease by affecting spike processing and glycosylation.
bioRxiv · Dec 15, 2021Microbiology
A. Muruato, M. Vu, B. A. Johnson, M. Davis-Gardner, A. R. Vanderheiden, K. Lokugamage, C. Schindewolf, P. A. Crocquet-Valdes, R. M. Langsjoen, J. A. Plante, K. S. Plante, S. C. Weaver, K. Debbink, A. L. Routh, D. H. Walker, , V. D. Menachery
This study creates a mouse-adapted SARS-CoV-2 strain that protects mice from lethal SARS-CoV challenge, demonstrating cross-strain immunity.
bioRxiv · May 3, 2021Microbiology
B. A. Johnson, X. Xie, B. Kalveram, K. G. Lokugamage, A. Muruato, J. Zou, X. Zhang, T. Juelich, J. K. Smith, L. Zhang, C. Schindewolf, M. N. Vu, A. Vanderheiden, J. A. Plante, K. S. Plante, , V. D. Menachery
This study shows that removing the furin cleavage site from SARS-CoV-2 increases replication in Vero cells but reduces replication in respiratory cells and pathogenesis in hamsters, while also decreasing neutralization susceptibility.
bioRxiv · Aug 26, 2020 · PreprintMicrobiology
J. Gribble, A. J. Pruijssers, M. L. Agostini, J. Anderson-Daniels, J. D. Chappell, X. Lu, L. J. Stevens, A. L. Routh, M. R. Denison
This study shows that the coronavirus proofreading exoribonuclease nsp14-ExoN is essential for RNA recombination and generates defective viral genomes.
bioRxiv · Apr 23, 2020Microbiology
E. V. Kozlova, S. Hegde, C. M. Roundy, G. Golovko, M. A. Saldana, C. E. Hart, E. R. Anderson, E. A. Hornett, K. Khanipov, V. L. Popov, M. Pimenova, Y. Zhou, Y. Fovanov, S. C. Weaver, A. L. Routh, , G. L. Hughes
This study investigates how microbial interactions in the mosquito gut affect Serratia colonization and blood feeding behavior in Ae. aegypti.
bioRxiv · Apr 14, 2020Microbiology