PPM1D is a neuroblastoma oncogene and therapeutic target in childhood neural tumors.
J. Milosevic, S. Fransson, M. Gulyas, G. Gallo-Oller, T. K. Olsen, D. Treis, M. Wickstrom, L. H. Elfman, B. Sveinbjornsson, F. Hertwig, C. Bartenhagen, S. Reinsbach, M. Wilhelm, F. Abel, N. Javanmardi, , P. Kogner
This study identifies PPM1D as an oncogene and therapeutic target in neuroblastoma by showing its role in p53 inactivation and tumor growth.
bioRxiv · Sep 4, 2020 · PreprintCancer Biology