M. Wilhelm

A systemic approach allows to identify the pedoclimatic conditions most critical in the susceptibility of a grapevine cultivar to esca/Botryosphaeria dieback

This study identifies pedoclimatic factors influencing esca-BD susceptibility in a grapevine cultivar through long-term field experiments and statistical analysis.

Unifying the analysis of bottom-up proteomics data with CHIMERYS

CHIMERYS deconvolves chimeric spectra in proteomic data, enabling unified analysis across DDA, DIA, and PRM experiments by accurately identifying and quantifying multiple peptides per spectrum.

Evaluating Bacterial Viability in Faecal Microbiota Transplantation: A Comparative Analysis of In Vitro Cultivation and Membrane Integrity Methods

This study compares in vitro cultivation and membrane integrity methods for assessing bacterial viability in frozen FMT stool filtrates, finding the latter more reliable and reproducible.

Structural implications of BK polyomavirus sequence variations in the major viral capsid protein Vp1 and large T-antigen: a computational study

This study analyzes BKPyV sequence variations in Vp1 and LTag using computational methods, finding high variability in Vp1 that may impact immune control and vaccine design, while LTag shows less variability but potential effects on T-cell epitopes.

Rheological behavior of Pluronic/Pluronic diacrylate hydrogels used for bacteria encapsulation

This study investigates the rheological properties of Pluronic/Pluronic diacrylate hydrogels with varying crosslinking fractions to correlate mechanical behavior with bacterial growth.

Real-time spectral library matching for sample multiplexed quantitative proteomics.

This paper introduces a real-time library searching workflow to improve quantitation in sample multiplexed proteomics by enabling intelligent scan triggering and peak selection.

Proteogenomic analysis reveals RNA as an important source for tumor-agnostic neoantigen identification correlating with T-cell infiltration

This study identifies RNA as a significant source of tumor-agnostic neoantigens, which correlate with T-cell infiltration in multiple cancer types.

p73 is required for vessel integrity controlling endothelial junctional dynamics through Angiomotin

This study identifies p73 as a regulator of endothelial junction dynamics through Angiomotin, showing its role in maintaining vessel integrity and preventing hyperpermeability.

Novel allosteric mechanism of dual p53/MDM2 and p53/MDM4 inhibition by a small molecule

This paper identifies a novel allosteric mechanism by which RITA and PpIX inhibit p53/MDM2 and p53/MDM4 interactions, offering a new approach for p53 reactivation in cancer therapy.

PPM1D is a neuroblastoma oncogene and therapeutic target in childhood neural tumors.

This study identifies PPM1D as an oncogene and therapeutic target in neuroblastoma by showing its role in p53 inactivation and tumor growth.