Metabolic clearance rate modeling: A translational approach to quantifying cerebral metabolism using hyperpolarized pyruvate.
J. T. Grist, N. Boegh, E. Hansen, A. Schneider, R. Healicon, V. Ball, J. Miller, S. Smart, Y. Couch, A. Buchan, D. Tyler, C. Laustsen
This paper introduces a model-free method to quantify cerebral metabolism using hyperpolarized pyruvate MRI and demonstrates its application in pre-clinical stroke and healthy human brain studies.
bioRxiv · Nov 2, 2022 · PreprintPhysiology