E. Hansen

Emerin deficiency drives MCF7 cells to an invasive phenotype

This study shows emerin deficiency in breast cancer cells leads to smaller, misshapen nuclei and increased metastasis, with emerin expression inversely correlating with cancer invasiveness in patient samples.

Metabolic clearance rate modeling: A translational approach to quantifying cerebral metabolism using hyperpolarized pyruvate.

This paper introduces a model-free method to quantify cerebral metabolism using hyperpolarized pyruvate MRI and demonstrates its application in pre-clinical stroke and healthy human brain studies.

Modifying adaptive therapy to enhance competitive suppression

This paper evaluates adaptive therapy for cancer, identifies three modifications to enhance competitive suppression, and shows they delay tumor progression and expand patient eligibility.

An adjunctive therapy administered with an antibiotic prevents enrichment of antibiotic-resistant clones of a colonizing opportunistic pathogen

This study shows that cholestyramine, when used with daptomycin, reduces the spread of antibiotic-resistant Enterococcus faecium in mice.

Antibiotics can be used to contain drug-resistant bacteria by maintaining sufficiently large sensitive populations

This study shows that maintaining large populations of drug-sensitive bacteria can delay the rise of drug-resistant bacteria using containment strategies.

Reporters of TCR signaling identify arthritogenic T cells in murine and human autoimmune arthritis

The paper identifies arthritogenic CD4 T cells in murine and human autoimmune arthritis using Nur77 as a marker of TCR signaling.

Energy-dependent transport at dural lymphatic vessels is necessary for Aβ brain clearance in Alzheimer's disease

The paper shows that energy-dependent transport in dural lymphatic vessels is critical for clearing Aβ in Alzheimer's disease, and blocking this pathway accelerates Aβ pathology.