The epithelial-specific ER stress sensor IRE1β enables host-microbiota crosstalk to affect colon goblet cell development
M. J. Grey, H. De Luca, D. V. Ward, I. A. M. Kreulen, S. E. Foley, J. R. Thiagarajah, B. A. McCormick, J. R. Turner, W. I. Lencer
This study shows IRE1β is essential for microbiota-induced goblet cell maturation and mucus barrier assembly in the colon, shaping gut microbiota composition through ER stress regulation.
bioRxiv · Jul 28, 2021 · PreprintCell Biology