W. I. Lencer

This study shows that bacterial sphingolipids worsen colitis by reducing IL-22 production from ILC3 cells in mice.

This study identifies a 7-residue motif in unfolded proteins recognized by IRE1LD, revealing how IRE1 detects misfolded proteins to trigger the UPR.

This study shows IRE1β is essential for microbiota-induced goblet cell maturation and mucus barrier assembly in the colon, shaping gut microbiota composition through ER stress regulation.

The paper identifies a structural motif in ceramide acyl chains that determines glycosphingolipid sorting via endocytic pathways and shows its dependence on cholesterol.

This study shows that cholera toxin subunit B induces membrane curvature only when bound to multiple GM1 receptors, highlighting the importance of structured clustering for this process.

This study shows IRE1β suppresses IRE1α signaling during ER stress by blocking its activation and disrupting a feedback loop that regulates IRE1 expression.