Loss of TRIM21 drives UVB-induced systemic inflammation by regulating DNA-sensing pathways
G. Tumurkhuu, R. Moore, G. Perri, L. Huo, A. Naveen Kumar, G. De Los Santos, D. Gibb, J. Carriere, Y. M. Yu, R. Abuav, D. Wallace, M. Ishimori, W. Shon, A. Dortfleutner, C. Stehlik, C. Jefferies
This study shows that loss of TRIM21 increases UVB-induced systemic inflammation by enhancing IFN expression through impaired STING signaling in mice.
bioRxiv · Apr 10, 2024Immunology