D. Varma

SAXS/MC studies of the mixed-folded protein Cdt1 reveal monomeric, folded over conformations

This study uses biophysical and computational methods to characterize the structure of human Cdt1, revealing 'folded over' conformations that suggest a scaffold function.

Nuclear lamin A-associated proteins are required for centromere assembly

This study shows that Lamin A-associated proteins are essential for centromere assembly during mitotic exit by interacting with centromere and kinetochore proteins.

The Ndc80-Cdt1-Ska1 complex constitute a minimal processive kinetochore-microtubule coupling unit

This study identifies a minimal molecular unit composed of Ndc80, Cdt1, and Ska1 that enables processive kinetochore-microtubule coupling during mitosis.

Muscle calcium stress cleaves junctophilin1, unleashing a gene regulatory programpredicted to correct glucose dysregulation

The paper identifies that muscle calcium stress leads to cleavage of junctophilin1, resulting in a gene regulatory program that improves glucose utilization in myoblasts.

The Ndc80 complex is essential for the initial kinetochore-microtubule capture during early mitosis

This study shows Ndc80 is essential for initial kinetochore-microtubule capture during prometaphase, working with dynein to ensure proper chromosome alignment.

Generation and diversification of recombinant monoclonal antibodies for studying mitosis

This study develops methods to generate low-cost, high-yield recombinant monoclonal antibodies and antibody fragments for studying mitosis and other applications.

Computational model demonstrates that Ndc80-associated proteins strengthen kinetochore-microtubule attachments in metaphase

The paper uses a computational model to show that Ndc80-associated proteins enhance kinetochore-microtubule attachments in metaphase by increasing displacement and rupture force.

Cdt1 modulates kinetochore-microtubule attachment stabilization via an Aurora B kinase-dependent mechanism

This paper shows Cdt1 binds microtubules and its phosphorylation by Aurora B kinase affects kMT stability and mitotic progression.

Antagonism between the dynein and Ndc80 complexes at kinetochores controls the stability of kinetochore-microtubule attachments during mitosis

This study shows that dynein and Ndc80 complexes antagonize each other's microtubule binding at kinetochores, and their coordinated function is critical for stable kinetochore-microtubule attachments during mitosis.