Author

D.-D. Vu

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Biophysics· 1

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Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:structural biology· 1

Frequent Co-Authors

A. Bonucci· 1 shared A. K. Aggarwal· 1 shared F. Ferrage· 1 shared G. Bouvignies· 1 shared J. M. STARK· 1 shared L. Carlier· 1 shared M. Blackledge· 1 shared M. Breniere· 1 shared

Activity by Year

2023-2023 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperBiophysics

A. Bonucci

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1 paper

Recent·Most cited

Multivalent interactions of the disordered regions of XLF and XRCC4 foster robust cellular NHEJ and drive the formation of ligation-boosting condensates in vitro

D.-D. Vu, A. Bonucci, M. Breniere, M. Cisneros-Aguirre, P. Pelupessy, Z. Wang, L. Carlier, G. Bouvignies, P. Cortes, A. K. Aggarwal, M. Blackledge, Z. Gueroui, V. Belle, J. M. STARK, M. M. Modesti, F. Ferrage

This study characterizes the multivalent interactions of XRCC4 and XLF CTRs, showing they form condensates that enhance DNA ligation in vitro and suggest roles in NHEJ dynamics and cancer biology.

bioRxiv · Jul 12, 2023Biophysics