Author

G. Bouvignies

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Assay:structural biology· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Assay:protein structure· 1

Frequent Co-Authors

M. Blackledge· 2 shared A. Bonucci· 1 shared A. K. Aggarwal· 1 shared A. K. Kancherla· 1 shared A. R. Camacho-Zarco· 1 shared D. Maurin· 1 shared D. P. Dowling· 1 shared D. P. Frueh· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersBiophysics

M. Blackledge

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Multivalent interactions of the disordered regions of XLF and XRCC4 foster robust cellular NHEJ and drive the formation of ligation-boosting condensates in vitro

D.-D. Vu, A. Bonucci, M. Breniere, M. Cisneros-Aguirre, P. Pelupessy, Z. Wang, L. Carlier, G. Bouvignies, P. Cortes, A. K. Aggarwal, M. Blackledge, Z. Gueroui, V. Belle, J. M. STARK, M. M. Modesti, F. Ferrage

This study characterizes the multivalent interactions of XRCC4 and XLF CTRs, showing they form condensates that enhance DNA ligation in vitro and suggest roles in NHEJ dynamics and cancer biology.

bioRxiv · Jul 12, 2023Biophysics

Multivalent dynamic colocalization of avian influenza polymerase and nucleoprotein by intrinsically disordered ANP32A reveals the molecular basis of human adaptation

A. R. Camacho-Zarco, L. Yu, T. Krischuns, S. Dedeoglu, D. Maurin, G. Bouvignies, T. Crepin, R. W. H. Ruigrok, S. Cusack, N. Naffakh, M. Blackledge

This study identifies how the E627K mutation in avian influenza polymerase enables multivalent colocalization with ANP32A and nucleoprotein in human cells, facilitating viral adaptation.

bioRxiv · Jul 8, 2023 · PreprintBiochemistry

Global Dynamics as Communication Sensors in Peptide Synthetase Cyclization Domains.

S. H. Mishra, A. K. Kancherla, K. A. Marincin, G. Bouvignies, S. Nerli, N. Sgourakis, D. P. Dowling, D. P. Frueh

The paper uses NMR to show that global dynamics in NRPS cyclization domains act as sensors for substrate interactions, enabling allosteric responses across the enzyme.

bioRxiv · Oct 6, 2021 · PreprintBiophysics