Tumor cell death by ferroptosis contributes to an immunosuppressive tumor microenvironment in syngeneic murine models of cancer
Nneka E. Mbah, Damien Sutton, Hanna S. Hong, Rashi Singhal, Rosa Elena Menjivar, Matthew D. Perricone, Heather Giza, Peter Sajjakulnukit, Amy L. Myers, Zeribe C. Nwosu, Jonathan M. Alektiar, Jason Lin, Daniel Long, Anthony C. Andren, Li Zhang, , Costas Andreas Lyssiotis
This study shows that ferroptosis in pancreatic cancer cells induces both pro- and anti-inflammatory signals, creating an immunosuppressive tumor microenvironment in mouse models.
Cancer & Metabolism · Apr 4, 2026Peer-reviewedCancer Biology