Megan D. Radyk

This study investigates the role of aspartate transaminases in pancreatic development and cancer progression using conditional knockout mice, finding that their loss does not affect tumor growth but impacts pancreas size in double knockout models.

The paper describes a novel lysosome-independent process called cathartocytosis, where cells eject unwanted material during reprogramming, distinct from autophagy.

This study shows that G6PD deficiency accelerates pancreatic acinar-to-ductal metaplasia by enhancing NADPH production for ROS management, highlighting a metabolic role in early tumorigenesis.