Intraflagellar transport-A deficiency attenuates ADPKD in a renal tubular- and maturation-dependent manner
Wei Wang, Luciane M. Silva, Henry H. Wang…·Pamela Vivian Tran
This study shows that deleting the IFT-A gene Thm1 in ADPKD mouse models has development-specific effects on kidney cysts, inflammation, and cilia length, suggesting environmental factors influence ciliary homeostasis and disease progression.